Increased haematological toxicity of methotrexate (decreased renal clearance of methotrexate by anti-inflammatory agents in general and displacement of methotrexate from its plasma protein binding by salicylates) (see section 4.3 Contraindications). Adults aged 16 years and over should take two tablets every four to six hours as needed. Do not take more than eight tablets in 24 hours.

Diuretics in combination with acetylsalicylic acid at higher doses: Decreased glomerular filtration via decreased renal prostaglandin synthesis. with concomitant treatment with anticoagulants (see interactions with other medicinal products and other forms of interaction),Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or So I'll comment on this a bit but bear in mind this is my perspective. Doesn't mean I'm right and not looking to get into a debate. Just the way the group thinks. Wear appropriate personal protective equipment (safety glasses, at a minimum), including during preparation and clean up.

anti-blood-clotting (anticoagulant) medicines such as warfarin, dabigatran, apixaban, edoxaban, rivaroxaban, heparin and low molecular weight heparins such as enoxaparin Increased hypoglycemic effect by high doses of acetylsalicylic acid via hypoglycaemic action of acetylsalicylic acid and displacement of sulphonylurea from its plasma protein binding.Dissolve in 1/2 cup (4 ounces/120 mL) of water. Drink after the tablets have dissolved all the way.